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Library Course Guide for: DRUG DISCOVERIES IN THE PHARMACEUTICAL INDUSTRY

Literature Research

Course Description

This course is a first-year seminar that provides a survey of past and current approaches that enable the discovery and development of therapeutic agents. Topics ranging from target identification to the formulation of therapeutic agents will be discussed.

Researching the Scholarly Literature and Using the Research

1. Pick the topic.

3. Identify major concepts to be researched and determine alternative/variations in terms

2. Do preliminary research to find what is out there or what is not; identify more alternatives/variations in terminology. Books are good. Josiah (Catalog)

4. Focus topic and concepts for intensified research.

Academic Search Premier (ASP) is great for exploring, focusing, and article finding.

5. Article-level finding

PubMed for finding biomed-related articles; Medical Subject Headings focus search. Must have Brown IP to take advantage of Findit so navigate thru the Library's access points.

Web of Science - use Cited Reference Search in Science Citation Index Expanded database to find; focus on authors and who they cite and who cited them.

Google Scholar - use to find cited bys not in WoS; quickly find if Brown has access to a reference in a paper with FindIt@Brown Full-text

6. Structure and properties of biological molecules

PubChem "Information on biological activities of small molecules," created as a part of the NIH's "Molecular Libraries Roadmap Initiative" as a portal to three linked databases - PubChem Substance, PubChem Compound, and PubChem Bioassay and a structure similarity search tool; Substance and Compound searched by names, synonyms, and keywords and linked to available biological property information and Bioassay searched by bioassay description.

7.Keep records of references checked - RefWorks, EndNote, or other

8. Write report with proper attribution for the works of others - check links on copyright and writing. Watch out for PLAGIARISM errors.

9. Learn from the experience to streamline research and write the next report for any discipline.